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AACR 2024 Presentations


AACR ANNUAL MEETING 2024
April 5-10, 2024
San Diego Convention Center, San Diego, CA 


April 7, 2024, 3:40 PM – 3:55 PM | Session MS.IM01.03 – Tumor-Targeted Immune Cell Engagers

Hart, K. C., et al. IGM-2644, a CD38xCD3 bispecific IgM T cell engager, shows enhanced anti-tumor activity compared to daratumumab in preclinical models of multiple myeloma. In:  Proceedings of the 115th Annual Meeting of the American Association for Cancer Research; 2024 April 5-10; San Diego, CA. Philadelphia (PA): AACR; 2024.

Abstract nr 1237
Presentation

 

April 8, 2024, 9:00 AM – 12:30 PM | Session PO.ET01.02 – Antibody-Drug Conjugates and Bispectific Antibodies

Desbois, M. et al. Novel combinations of aplitabart, a DR5 agonist IgM antibody, with ADCs or chemotherapeutic agents lead to robust anti-tumor responses in solid tumor models.  In:  Proceedings of the 115th Annual Meeting of the American Association for Cancer Research; 2024 April 5-10; San Diego, CA. Philadelphia (PA): AACR; 2024.

Abstract nr 1899/10
Poster

 

April 10, 2024, 9:00 AM – 12:30 PM |  Session PO.IM01.18 – Targeted Immune Cell Engagers

Xue, J. et al. Costimulatory IgM T-cell engagers with enhanced and durable cytotoxicity.  In:  Proceedings of the 115th Annual Meeting of the American Association for Cancer Research; 2024 April 5-10; San Diego, CA. Philadelphia (PA): AACR; 2024.

Abstract nr 6726/24
Poster

 

Webinar: IgM Antibodies and Other Alternative Frameworks: Promise and Progress

Link to Webinar 

April 26, 2023

Scientific innovations and advancements in antibody-based therapies, including alternative approaches using IgE, IgA, and IgM antibodies, are paving the way towards a new era of antibody medicines. Further development of new approaches beyond traditional IgG based efforts, may allow more patients with serious diseases to benefit. Early efforts to utilize these antibodies, with a focus on IgM, were challenging but significant progress has been made recently which highlights their potential as new therapeutic platforms.

IgM antibodies have a unique structure that addresses many of the limitations of traditional bivalent IgG antibodies. With 10 binding sites and a J-chain that can interact with different receptors, engineered IgM antibodies represent a new class of potential therapeutics that combine multivalency, high avidity, and high specificity.

These attributes have enabled the development of IgM antibodies that can more effectively bind and cluster receptors for induction of apoptosis, including IgM agonist of death receptor 5 (DR5), and bispecific T-cell engagers for treatment of solid and hematologic cancers, autoimmune/inflammatory diseases, and infectious diseases.

This webinar will discuss the unique attributes of these antibodies and the potential applications of this approach to address unmet needs and create new opportunities for patients.

Key Topics

  • Discuss the use of larger, alternative isotypes including IgE, IgA, and IgM as therapeutic antibody candidate,
  • Discuss advancements in IgM antibody development and history of engineering and therapeutic efforts,
  • Review new approaches to agonist cell signaling and bispecific binding of disease-specific targets with engagement of T cells
  • Present exciting clinical results that bring promise to realizing therapeutic potential of engineered IgM antibodies.

 

Speakers:

William (Bill) Strohl, PhD, President, BiStro Biotech Consulting LLC
 Dr. William (Bill) Strohl has over 35 years of experience in biopharmaceutical research, including a 17-year academic career in academia at The Ohio State University.  He has also led numerous R&D efforts within the pharmaceutical industry including Merck and Janssen. During his time at J&J, Dr. Strohl and his teams placed more than 30 highly innovative, novel biologics into development and initiated new areas of research in gene and cell therapy to augment the long-standing traditional efforts in antibodies and protein therapeutics. He has published over 140 papers as well as written and edited several reference textbooks including one on Therapeutic Antibody Engineering and Microbiology.

Bruce Keyt, PhD, Chief Scientific Officer at IGM Biosciences
Dr. Bruce Keyt is the Chief Scientific Officer of IGM Biosciences, a clinical stage biotechnology company based in Mountain View, California.  He has led the research, early development and manufacturing efforts of IGM since 2012 and has helped develop IGM’s pipeline of engineered IgM antibodies. Dr. Keyt has over 40 years of experience in the biopharmaceutical industry including at Abgenix, Millennium Pharmaceuticals, and Genentech.  He has made significant contributions to the discovery and development of a number of novel biologics including Vectabix, Avastin, Lucentis, TNKase-tPA, Activase-tPA and Kogenate Factor VIII.  He has co-authored 60 scientific articles and is a co-inventor on more than 30 granted US patents.  Dr. Keyt received a B.A. in Chemistry from Washington University in St. Louis and a Ph.D. in Biochemistry and Pharmacology from Tufts University School of Medicine.
bruce@igmbio.com

Moderator: Janice Reichert, PhD, Chief Operating Officer of The Antibody Society
Dr. Janice Reichert is the Chief Operating Officer of The Antibody Society and is an internationally recognized expert in the development of antibody therapeutics. She is Founder and Editor-in-Chief of mAbs, a peer-reviewed, PubMed-indexed biomedical journal that focuses on topics relevant to antibody research and development. Dr. Reichert has published extensively on development trends for antibody therapeutics, and she has presented her research results as an invited speaker at conferences held worldwide. She is co-editor of the Handbook of Therapeutic Antibodies, and serves on the editorial boards of several biomedical journals. Dr. Reichert received her PhD in Chemistry from the University of Pennsylvania and did her post-doctoral training at Harvard Medical School.
https://www.antibodysociety.org

 

Link to Webinar 

AACR 2023 Poster Presentations

AACR ANNUAL MEETING 2023
April 14 – 19, 2023
Orange County Convention Center, Orlando, Florida

Apr. 17, 2023, 1:30 PM – 5:00 PM | Section 23
2933 – Novel CD123xCD3 bispecific IgM antibody, IGM-2537, potently induces T-cell mediated cytotoxicity of acute myeloid leukemia cells with minimal cytokine release
Abstract
Poster

Apr. 17, 2023, 1:30 PM – 5:00 PM | Section 24
2959 – Novel CD38xCD3 bispecific IgM T cell engager, IGM-2644, potently kills multiple myeloma cells though complement and T cell dependent mechanisms
Abstract
Poster

Apr. 18, 2023, 9:00 AM – 12:30 PM | Section 24
4120 – Depletion of tissue-resident B cells by a CD20xCD3 IgM bispecific T cell engager in cynomolgus monkeys demonstrates effective tissue penetration and potent target cell killing
Abstract
Poster 

Apr. 18, 2023, 1:30 PM – 5:00 PM | Section 44
5660 – IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell mediated cytotoxicity of PD-L1-positive tumor cells
Abstract
Poster

Apr. 19, 2023, 9:00 AM – 12:30 PM | Section 15
6123 – Characterization of the synergistic tumor cytotoxicity of agonistic DR5 IgM antibody IGM-8444 with chemotherapeutic agents
Abstract
Poster

Apr. 17, 2023, 9:00 AM – 12:30 PM | Section 46
CT052 / 10 – A phase 1/2 randomized study of imvotamab monotherapy and in combination with loncastuximab tesirine in relapsed/refractory non-Hodgkin lymphomas
Abstract
Poster