Research Associate/Senior Research Associate, Antibody Pharmacology

We are looking for a Research Associate/Senior Research Associate with a background in Pharmacology, Immuno-oncology, or Immunology to join our growing and friendly team during this exciting time in our expansion. You will play an integral role in the pre-clinical development of novel immuno-oncology therapeutics. In this position, you will perform standard immuno-assays, in vitro and in vivo studies, think laterally to solve problems, constantly improve work practices, and work productively as part of a team.

Responsibilities:

  • Develop and execute cell-based assays.
  • Perform ELISA and other immunoassays of cytokines/analytes.
  • Utilize multicolor flow cytometry and other state-of-the-art instruments in analysis.
  • Perform in vivo antibody pharmacology studies.
  • Execute basic biochemical assays (eg. Western blot).
  • Communicate own work effectively orally and in writing; present data in group meeting.
  • Thoroughly and accurately document experimental activities in laboratory notebooks.

 Qualifications:

  • BS or MS in Pharmacology, Immunology, Cell Biology or related scientific discipline.
  • 3-5 years of relevant industry experience with biologics.
  • Hands-on experience with quantitating protein analytes using ELISA and/or multiplex immunoassays.
  • Hands-on experience with preclinical animal models for pharmacology, immuno-oncology or immunology studies.
  • Hands-on experience with cell based assays, and flow cytometry.
  • Hands-on experience with antibody pharmacology is a plus.
  • Proficient with basic computer programs routinely used in a lab such as MS Word, Excel, and PowerPoint, GraphPad Prism, and FlowJo.
  • Highly organized with reliable time-keeping skills and able to maintain a detailed and well-organized notebook.
  • Must have strong interpersonal and communication skills.
  • Being a team player and respectful of others is a must.
  • Able to thrive in a fast-paced, start-up environment.
  • Able to commute to Mountain View.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 

Director, Antibody Pharmacology

Our Preclinical Sciences group is seeking a Director of Antibody Pharmacology.   In this critical role, you will be responsible for investigating the in vivo pharmacology aspects of drug discovery programs in a variety of disease areas, and at various stages of preclinical and/or development.  You’ll collaborate closely with both internal and external scientists.  In this position, you’ll report to the VP of Preclinical Sciences, and will actively participate in the expansion of the Preclinical team.

Requirements:

  • PhD in Pharmacology, Molecular Biology, Cell Biology or related field.
  • 7 + years of relevant industry experience in a biotech or biopharmaceutical setting.
  • Proven in vivo physiology and pharmacology skills in rodent and non-rodent animal models, and experience overseeing the design, execution and interpretation of non-clinical in vivo pharmacology studies and preparing successful IND submissions.
  • Extensive experience leading the in vivo pharmacology aspects of drug discovery and development from target validation to IND-enabling studies.
  • Demonstrated creativity and novel approaches to solving scientific problems.
  • Knowledge of preclinical and clinical biomarker discovery and development.
  • Deep understanding of preclinical PK/PD/efficacy relationships and their translation to the clinic.
  • Extensive experience with engaging and managing external in vivo efforts with contract research organizations, as well as with academic collaborators.
  • A collaborator who communicates in an open, clear, complete, timely and consistent manner.
  • Able to work in a fast-paced, start-up environment.
  • Able to commute to Mountain View.

 Responsibilities:

  • Lead the antibody pharmacology aspects of multiple product development projects, provide in vivo physiology and pharmacology expertise to successfully bringing programs to IND submission.
  • Propose, plan and manage study execution at external CROs, and data interpretation to characterize the company’s drug candidates and their in vivo mechanism of action to move programs from discovery to clinical development.
  • Investigate the pharmacokinetics, pharmacodynamics and biodistribution of IgM- and IgA-based therapeutics.
  • Plan and implement translational research including pharmacodynamic markers of target engagement, biomarkers predictive of or correlating with clinical efficacy and disease biology.
  • Contribute to preparation of study reports, regulatory filings and project presentations.
  • Interface with external partners, clinical and academic collaborators, and CROs.
  • Provide updates and advice to Preclinical, project teams and senior management, including evaluation of data and their potential impact on drug programs and clinical/regulatory strategy.
  • Keep abreast of emerging novel and translational animal models that could facilitate identification and validation of new targets or development of new therapeutics.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
Apply to this position