Senior/Principal Scientist

The Discovery Biology group is seeking a Senior/Principal Scientist with deep experience in biologics, focused on antibody therapeutics. The ideal candidate will also have a solid background in the construction and characterization of bispecific antibodies, especially T-cell engagers. Prior experience with program leadership is preferred. This is a critical position in the Discovery Biology group and will have the opportunity to collaborate across groups to contribute to and lead multiple fast-moving bispecific IgM projects.

Responsibilities:

  • Lead effort on new TAA X CD3 bispecific IgM project(s).
  • Contribute to target selection and due diligence of candidate tumor associated antigens.
  • Rapidly acquire expert knowledge on one or more tumor targets/therapeutic areas.
  • Collaborate with molecular biology and protein production/purification/analytics teams to generate material for in vitro and early in vivo studies.
  • Work extensively with internal and external collaborators to make and test competing bispecific molecules and keep abreast of literature and clinical trial data in field.
  • Design and execute experiments for advanced in vivo studies in collaboration with preclinical sciences team.
  • Collaborate with Process Sciences and Manufacturing team to build production cell lines.
  • Generate reports for supporting IND filing and patents as program moves from Research to Manufacturing and Development.

Qualifications:

  • Ph.D. in biological sciences or related fields with 6 + years of post-PhD experience in biopharma industry, preferably in a startup environment.
  • Prior experience with generation of and optimization of biologics for multiple therapeutic indications.
  • Demonstrated experience with all phases of preclinical research with antibody and antibody-like biologics – molecular biology, mammalian cell culture, transfection, protein production, purification, characterization using in vitro biochemical and cell biology assays.
  • Prior knowledge and experience working with bispecific antibodies and sound understanding of T-cell biology.
  • Excellent organization, interpersonal, and communication skills, ability to work in a fast-paced environment.
  • Ability to effectively mentor and develop Research Associates and lead projects in a matrix organization.
  • Demonstrated track record of publications in top-tier journals and/or patents.
  • Being a consummate team player and respectful of others is a must.
  • Able to commute to Mountain View.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
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Research Associate, Protein Purification

We are seeking a Research Associate with a background in immunological, biochemical, and protein chemistry techniques. In this important position, you will support the Discovery Biology group primarily in protein characterization (SDS-PAGE, ELISA, western blots, Endotoxin assays, etc) and functional assays in cell-based systems (Luminescent or flow cytometry based assays).

Responsibilities:

  • Perform protein purification of small to large scale antibodies using AKTA PRIME, AKTA START and AKTA pure.
  • Measure supernatant titer by ELISA or SEC.
  • Characterize antibody by SEC, UV, Endotoxin assay, SDS-PAGE, Western Blots.
  • Prepare Data Package and CofA.
  • Perform high throughput purification using Hamilton Nimbus.
  • Stable/transient plasmid transfection of suspension/adherent mammalian cell cultures.
  • Ensure high-quality, timely documentation in electronic laboratory notebooks and technical reports.
  • Work as part of a cross-functional team.

Qualifications:

  • Bachelor’s degree (BS) in Cell Biology, Molecular Biology, Biochemistry with 2 years of  experience, preferably in a startup biotech environment.
  • Experience with protein purification and characterization assays (SDS-PAGE, ELISA, western blots, Endotoxin assays, etc).
  • Knowledge of basic computer programs routinely used in a lab such as MS Word, Powerpoint, Excel, GraphPad etc; ability to quickly learn and master new instrument software and programs.
  • Excellent organization, interpersonal, and communication skills.
  • Being a team player and respectful of others is a must.
  • Experience with mammalian cell culture and micro-titer plate based readouts for cell proliferation and/or killing.
  • Experience in maintaining thorough lab records, and adhering to health and safety regulations.
  • Able to thrive in a fast-paced, start-up environment.
  • Must be able to commute to Mountain View.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
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Senior Research Associate

IGM Biosciences is seeking a Senior Research Associate with a background in immunological, biochemical, and protein chemistry techniques to join our rapidly growing team. In this position, you will support the Discovery Biology group primarily in protein characterization (SDS-PAGE, ELISA, western blots, Endotoxin assays, etc.) and functional assays in cell-based systems (Luminescent or flow cytometry based assays).

Qualifications:

  • Master’s degree in biological sciences or related field, or Bachelor’s degree (BS) with 2 years’ experience, preferably in a startup biotech environment.
  • Experience with cell-based assays particularly using flow cytometry.
  • Knowledge of basic computer programs routinely used in a lab such as MS Word, Powerpoint, Excel, GraphPad, etc. Must be able to quickly learn and master new instrument software and programs.
  • Excellent organization, interpersonal, and communication skills.
    Being a team player and respectful of others is a must.
  • 5 years of combined research experience in either academia or industry, with a strong interest in multidisciplinary approaches to molecular biology, chemistry, and immunology research.
  • Experience with mammalian cell culture and micro-titer plate based readouts for cell proliferation and/or killing.
  • Experience with multi-color flow cytometry assays and flowjo software.
  • Experience with protein characterization assays (SDS-PAGE, ELISA, western blots, Endotoxin assays, etc).
  • Experience in maintaining thorough lab records, and adhering to health and safety regulations.
  • Able to thrive in a fast-paced, start-up environment.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
Apply to this position