IGM Biosciences Announces Pricing of Initial Public Offering

September 17, 2019 at 8:46 PM EDT

MOUNTAIN VIEW, Calif. — IGM Biosciences, Inc. (Nasdaq: IGMS) today announced the pricing of its initial public offering of 10,937,500 shares of its common stock at a price to the public of $16.00 per share. The shares are expected to begin trading on The Nasdaq Global Select Market on September 18, 2019 under the symbol “IGMS.” The offering is expected to close on September 20, 2019, subject to customary closing conditions. The gross proceeds from the offering, before deducting underwriting discounts and commissions and estimated offering expenses payable by IGM, are expected to be approximately $175.0 million. In addition, the underwriters have a 30-day option to purchase up to 1,640,625 additional shares of common stock at the initial public offering price less underwriting discounts and commissions.

Jefferies, Piper Jaffray, Stifel and Guggenheim Securities are acting as joint book-running managers for the offering.

A registration statement relating to the offering has been filed with the United States Securities and Exchange Commission and was declared effective on September 17, 2019. The offering is made only by means of a prospectus. When available, a copy of the prospectus relating to this offering may be obtained from: Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, by telephone at (877) 821-7388 or by email at Prospectus_Department@Jefferies.com; Piper Jaffray & Co, Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, by telephone at (800) 747-3924 or by email at prospectus@pjc.com; Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720 or by email at syndprospectus@stifel.com; or Guggenheim Securities, LLC, Attention: Equity Syndicate Department, 330 Madison, 8th Floor, New York, NY 10017, by telephone at (212) 518-9658 or by email at GSEquityProspectusDelivery@guggenheimpartners.com.

This press release does not constitute an offer to sell or a solicitation of an offer to buy, nor will there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful before registration or qualification under the securities laws of that state or jurisdiction.

About IGM Biosciences, Inc.

Headquartered in Mountain View, California, IGM Biosciences is a biotechnology company focused on creating and developing engineered IgM antibodies for the treatment of cancer patients. Since 2010, IGM Biosciences has worked to overcome the manufacturing and protein engineering hurdles that have limited the therapeutic use of IgM antibodies. Through its efforts, IGM Biosciences has created a proprietary IgM technology platform for the development of IgM antibodies for those clinical indications where their inherent properties may provide advantages as compared to IgG antibodies.

CONTACT:

Argot Partners
David Pitts
212-600-1902
igmbio@argotpartners.com

Accounting Manager

We are seeking a highly motivated, detail-oriented customer service focused professional to work in our dynamic, fast-paced environment.  As our Accounting Manager, you will be responsible for corporate accounting operations and you’ll contribute to the continuing success of IGM. This position reports to the Controller.

Responsibilities:

  • Maintain the general ledger of the company.
  • Manage the monthly close process, including preparation/review of journal entries, allocations, and account reconciliations.
  • Manage accruals, including clinical trial and other R&D accruals.
  • Assist with the preparation and completion of forms 8-K, 10-Qs, and 10-K.
  • Prepare and review audit support schedules.
  • Produce monthly financial reporting for the executive team on a timely basis.
  • Make and implement recommendations to improve accounting policies and procedures.
  • Ensure SOX compliance by monitoring accounting policies, procedures and internal controls.
  • Provide technical accounting expertise and knowledge.
  • Support the organization in maintaining a work environment focused on quality and that fosters learning, open communication, collaboration, integration and teamwork.

 Qualifications:

  • Bachelor’s Degree in Accountancy.
  • The ideal candidate will have Big 4 CPA experience.
  • Minimum of 7 years of increasingly responsible accounting and reporting experience, preferably with public companies.
  • Strong understanding of US GAAP and experience with SEC Regulations.
  • Previous experience with mid-sized ERP systems.
  • Computer literacy required, with the ability to navigate computer systems with little or no assistance. Proficiency in MS Office specifically with Outlook, Word, Excel and PowerPoint.
  • Must possess the ability to multi-task and work in time sensitive situations to meet deadlines.
  • High level of attention to detail.
  • Must possess excellent interpersonal communication (oral and written).
  • Must have organizational and project planning skills.
  • Ability to effectively work and communicate with all levels of employees throughout the company.
  • Previous experience in the life sciences, biotechnology, or pharmaceutical industry highly desired.
  • Ability to self-motivate and function independently.
  • Collaborative and team oriented.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

Research Associate/Senior Research Associate, Antibody Pharmacology

We are looking for a Research Associate/Senior Research Associate with a background in Pharmacology, Immuno-oncology, or Immunology to join our growing and friendly team during this exciting time in our expansion. You will play an integral role in the pre-clinical development of novel immuno-oncology therapeutics. In this position, you will perform standard immuno-assays, in vitro and in vivo studies, think laterally to solve problems, constantly improve work practices, and work productively as part of a team.

Responsibilities:

  • Develop and execute cell-based assays.
  • Perform ELISA and other immunoassays of cytokines/analytes.
  • Utilize multicolor flow cytometry and other state-of-the-art instruments in analysis.
  • Perform in vivo antibody pharmacology studies.
  • Execute basic biochemical assays (eg. Western blot).
  • Communicate own work effectively orally and in writing; present data in group meeting.
  • Thoroughly and accurately document experimental activities in laboratory notebooks.

 Qualifications:

  • BS or MS in Pharmacology, Immunology, Cell Biology or related scientific discipline.
  • 3-5 years of relevant industry experience with biologics.
  • Hands-on experience with quantitating protein analytes using ELISA and/or multiplex immunoassays.
  • Hands-on experience with preclinical animal models for pharmacology, immuno-oncology or immunology studies.
  • Hands-on experience with cell based assays, and flow cytometry.
  • Hands-on experience with antibody pharmacology is a plus.
  • Proficient with basic computer programs routinely used in a lab such as MS Word, Excel, and PowerPoint, GraphPad Prism, and FlowJo.
  • Highly organized with reliable time-keeping skills and able to maintain a detailed and well-organized notebook.
  • Must have strong interpersonal and communication skills.
  • Being a team player and respectful of others is a must.
  • Able to thrive in a fast-paced, start-up environment.
  • Able to commute to Mountain View.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 

Analytical Research Associate

We are seeking an experienced, hands-on team member to join IGM as an Analytical Research Associate.  In this important role, you will support IgM characterization and Process Development for the IND and clinical stage IGM biotherapeutics.

Responsibilities:

  • Following written SOPs for routine analysis of antibody products with UV-Vis, HPLC, SDS-PAGE, cIEF, DLS, qPCR, and ELISA.
  • Routinely determine endotoxin in antibody solutions.
  • Maintaining HPLC, UV-Vis, DLS, CE, and qPCR instruments.
  • Maintaining an organized analytical lab environment in compliance with safety regulations.
  • Practicing GLP for all lab related activities including but not limited to buffer preparation, sample handling, and analytical method execution.
  • Expected to provide analytical support for process development, analytical method development, and drug formulation development.
  • Expected to keep excellent documentation and to prepare SOPs, protocols, and technical documents.
  • Encouraged to explore and identify new analytical technologies.
  • Expected to analyze scientific/technical data and present data in project team meetings.

Qualifications:

  • BS in Analytical Chemistry or related fields with 5+ years of hands-on laboratory experience, preferably in the biotech/biopharmaceutical setting.
  • Experience with standard biological analytical methods SDS-PAGE, HPLC (SEC-, IEX-, RP-, EC-, HIC-), capillary electrophoresis (CE-SDS, cIEF), particle analysis by DLS, UV-Vis spectroscopy, and ELISA is required.
  • Experience with tissue culture technique and biologics sample handling.
  • Able to work independently on multiple projects simultaneously.
  • Strong interpersonal skills and excellent communication skills are a must.
  • Physical ability to lift up to 40lbs and work at the lab bench for extended periods of time.
  • Being a team player and respectful of others is a must.
  • Able to thrive in a fast-paced, start-up environment.
  • Able to commute to Mountain View.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 

Clinical Scientist

We are seeking an experienced clinical scientist to successfully strategize and execute a clinical development plan for engineered IgM-based pipeline molecules, starting from First in Human Phase I studies, primarily conducted in the U.S and primarily in Oncology indications.

Qualifications:

  • Advanced scientific or clinical degree (eg PhD, PharmD, MPH, MD, etc).
  • 5 or more years clinical trial experience (must demonstrate a minimum of 2 years clinical trial experience in pharma/biotech industry).
  • Data listing review experience is preferred.
  • Experience authoring experimental protocols and/or study results and conclusions.
  • Relevant therapeutic area experience.
  • In-depth understanding of Phase I (and beyond) drug development.
  • Experience in the principles and techniques of data analysis, interpretation.
  • Sound knowledge of medical aspects of GCP (Good Clinical Practice), ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use), FDA, EMEA, NICE and other relevant guidelines and regulations.
  • Proven abilities to perform Clinical Scientist responsibilities with increasing expertise and independence.
  • Track record of working well with other scientists and clinicians is highly valued.
  • Must be able to commute to Mountain View.
  • Able to travel (<20%).

Responsibilities:

  • Participate in Development teams, and clinical trial teams.
  • Work with Clinical Development, Clinical Operations, Drug Safety, Biostatistics, Regulatory, and Biomarker groups.
  • Develop clinical strategies.
  • Lead clinical trial protocol development, and amendments.
  • Literature research and review in disease/program area.
  • Assist with completion and submission of regulatory filings and other regulatory documentation.
  • Work with clinical teams on study site visits, and protocol training.
  • Contribute to Investigator Meetings, and Investigator/study calls.
  • Work with Clinical Operations and Medical Directors to develop consistent language and criteria for the Informed Consent Form (ICF), protocol eligibility, protocol dose modification, protocol safety, Case Report Forms (CRFs), CRF instructions, etc.
  • Assist with Medical monitoring inquiries, and participates in safety meetings and tracks, analyzes and reports any potential safety events.
  • Work with Medical Directors, Clinical Operations, Biostatistics, and other groups to conduct clinical review of study data.
  • Review, analyze, and discuss clinical study reporting documents with Medical Directors.
  • Slide deck preparation for communicating clinical development plans, clinical trial timelines, clinical data.
  • Support Medical Directors in preparing for internal/external meetings and presentations
  • Drafting and/or reviews of abstracts, posters, and coordinates further reviews with internal partners and stakeholders.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
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Senior Research Associate, Discovery Biology

We are seeking a Senior Research Associate in the Discovery Group with a background in immunological, biochemical, and protein chemistry techniques. In this important position, you should have a good understanding of human and mouse immune systems, extensive experience in various immunological assays such as recall antigen assay, mixed lymphocyte reaction assay etc. You should also have experience with small scale protein production, purification and characterization. Experience with high throughput cell-based assays and assay automation with liquid handling robots is also highly desired.

Qualifications:

  • Master’s degree in biological sciences or related field with 2 years’ experience, or Bachelor’s degree (BS) with 4 years’ experience in biotech industry.
  • Familiar with human and mouse immune systems. Hands on experience with various immunological assays such as T cell activation assays, cytokine release assays, recall antigen assay, and mixed lymphocyte reaction assay, etc. Extensive experience in multi-color flow cytometry is required.
  • Experience with mammalian cell culture and transfection, protein purification and characterization (SDS-PAGE, ELISA, western blots, Endotoxin assays, etc.).
  • Experience with high throughput cell-based assays with imaging and flow cytometry readouts, and assay automation using liquid handling robots is highly desired.
  • Knowledge of basic computer programs routinely used in a lab such as MS Word, PowerPoint, Excel, GraphPad etc; ability to quickly learn and master new instrument software and programs.
  • Excellent organization, interpersonal, and communication skills.
  • Being a team player and respectful of others is a must.
  • Must be able to commute to Mountain View.

Responsibilities:

  • Perform small scale protein production, purification and characterization (SDS-PAGE, ELISA, western blots, Endotoxin assays, etc.) of candidate antibodies to support multiple therapeutic IgM projects.
  • Isolate PBMCs and immune cell subsets from buffy coat or whole blood samples. Perform in vitro functional assays such as cytotoxicity assays, T cell activation assays, cytokine release assays, recall antigen assay, and mixed lymphocyte reaction assay to evaluate candidate antibodies.
  • Perform ELISA and flow cytometry assays to analyze ex vivo samples from PK/PD animal studies, including PK ELISAs, cytokine analysis, immunophenotyping, etc.
  • Perform data analysis and generate technical reports. Ensure high-quality and timely documentation in electronic lab notebooks.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

Scientist/Senior Scientist

We are looking for a Scientist/Senior Scientist with a strong background in Immuno-oncology or Immunology to join our growing and friendly team during this exciting time in our expansion. You will play an integral role in the pre-clinical development of novel immuno-oncology therapeutics. We are looking for candidates that are highly skilled, motivated and creative scientists with hands-on experience in immunology, oncology, animal models and molecular biology with the ability to lead preclinical stage programs through conducting early stage proof-of-concept in vitro and in vivo studies and work productively as part of a team.

Qualifications:

  • PhD in immunology/oncology with a minimum of 2-5 years of industry experience.
  • Experience working with in vitro and in vivo models for proof-of-concept studies.  Ability to establish mechanistic in vitro immune cell-based assays with primary human immune cells.
  • Understanding of and ability to execute in vivo models with ability to select relevant models for mechanistic and efficacy studies.
  • Experience in flow cytometry and general molecular biological techniques including Western blotting, ELISAs, q-PCR etc.
  • Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment.
  • Experience training and supervising direct reports.
  • Proficient with basic computer programs routinely used in a lab such as MS Word, Excel, and PowerPoint, GraphPad Prism, and FlowJo.
  • Highly organized with reliable time-keeping skills and able to maintain a detailed and well-organized notebook.
  • Must have strong interpersonal and communication skills.
  • Being a team player and respectful of others is a must.
  • Able to thrive in a fast-paced, start-up environment.
  • Able to commute to Mountain View.

Responsibilities:

  • Lead research efforts to generate proof-of-concept in vitro and in vivo data for new early stage immuno-oncology programs.
  • Work closely with collaborators and CROs during the preclinical discovery and development stages.
  • Accountable for project strategy, delivery, communication and follow-up.
  • Presentation of results at internal and external meetings.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
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Patent Agent

We are seeking an experienced patent agent to help manage our growing patent portfolio. In this important position you will use your scientific and legal skills to develop and implement patent strategies in coordination with the legal team, and to identify and communicate risks. This position will directly report to our VP, Intellectual Property.

Qualifications:

  • Patent Agent with USPTO Registration Number.
  • 4+ years of experience in preparing and prosecuting patent applications in a molecular biology-related field, either in-house or in a law firm.
  • PhD or equivalent in a molecular biology-related field, or B.S. or M.S. plus 6+ years of relevant laboratory experience.
  • Experience working in the biotechnology industry.
  • High level of professionalism and motivation, ability to work independently but also as part of a team.
  • Ability to take initiative to identify and complete tasks.
  • Ability to manage multiple projects with rapidly changing priorities.
  • Excellent writing and communication skills.
  • Exemplary time management skills, organization, and attention to detail.

Responsibilities: 

  • Actively coordinate with our research and development teams to identify new inventions as well as to devise and implement strategies for patent protection over the life cycle of product candidates.
  • Prepare and prosecute US patent applications.
  • Assist in the development of coordinated global patent strategies.
  • Perform freedom to operate and patentability searches.
  • Evaluate and monitor patent portfolios of third parties.
  • Communicate IP guidance to IGM management.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
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Senior/Principal Scientist

The Discovery Biology group is seeking a Senior/Principal Scientist with deep experience in biologics, focused on antibody therapeutics. The ideal candidate will also have a solid background in the construction and characterization of bispecific antibodies, especially T-cell engagers. Prior experience with program leadership is preferred. This is a critical position in the Discovery Biology group and will have the opportunity to collaborate across groups to contribute to and lead multiple fast-moving bispecific IgM projects.

Responsibilities:

  • Lead effort on new TAA X CD3 bispecific IgM project(s).
  • Contribute to target selection and due diligence of candidate tumor associated antigens.
  • Rapidly acquire expert knowledge on one or more tumor targets/therapeutic areas.
  • Collaborate with molecular biology and protein production/purification/analytics teams to generate material for in vitro and early in vivo studies.
  • Work extensively with internal and external collaborators to make and test competing bispecific molecules and keep abreast of literature and clinical trial data in field.
  • Design and execute experiments for advanced in vivo studies in collaboration with preclinical sciences team.
  • Collaborate with Process Sciences and Manufacturing team to build production cell lines.
  • Generate reports for supporting IND filing and patents as program moves from Research to Manufacturing and Development.

Qualifications:

  • Ph.D. in biological sciences or related fields with 6 + years of post-PhD experience in biopharma industry, preferably in a startup environment.
  • Prior experience with generation of and optimization of biologics for multiple therapeutic indications.
  • Demonstrated experience with all phases of preclinical research with antibody and antibody-like biologics – molecular biology, mammalian cell culture, transfection, protein production, purification, characterization using in vitro biochemical and cell biology assays.
  • Prior knowledge and experience working with bispecific antibodies and sound understanding of T-cell biology.
  • Excellent organization, interpersonal, and communication skills, ability to work in a fast-paced environment.
  • Ability to effectively mentor and develop Research Associates and lead projects in a matrix organization.
  • Demonstrated track record of publications in top-tier journals and/or patents.
  • Being a consummate team player and respectful of others is a must.
  • Able to commute to Mountain View.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
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Research Associate, Protein Purification

We are seeking a Research Associate with a background in immunological, biochemical, and protein chemistry techniques. In this important position, you will support the Discovery Biology group primarily in protein characterization (SDS-PAGE, ELISA, western blots, Endotoxin assays, etc) and functional assays in cell-based systems (Luminescent or flow cytometry based assays).

Responsibilities:

  • Perform protein purification of small to large scale antibodies using AKTA PRIME, AKTA START and AKTA pure.
  • Measure supernatant titer by ELISA or SEC.
  • Characterize antibody by SEC, UV, Endotoxin assay, SDS-PAGE, Western Blots.
  • Prepare Data Package and CofA.
  • Perform high throughput purification using Hamilton Nimbus.
  • Stable/transient plasmid transfection of suspension/adherent mammalian cell cultures.
  • Ensure high-quality, timely documentation in electronic laboratory notebooks and technical reports.
  • Work as part of a cross-functional team.

Qualifications:

  • Bachelor’s degree (BS) in Cell Biology, Molecular Biology, Biochemistry with 2 years of  experience, preferably in a startup biotech environment.
  • Experience with protein purification and characterization assays (SDS-PAGE, ELISA, western blots, Endotoxin assays, etc).
  • Knowledge of basic computer programs routinely used in a lab such as MS Word, Powerpoint, Excel, GraphPad etc; ability to quickly learn and master new instrument software and programs.
  • Excellent organization, interpersonal, and communication skills.
  • Being a team player and respectful of others is a must.
  • Experience with mammalian cell culture and micro-titer plate based readouts for cell proliferation and/or killing.
  • Experience in maintaining thorough lab records, and adhering to health and safety regulations.
  • Able to thrive in a fast-paced, start-up environment.
  • Must be able to commute to Mountain View.

IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

 
 
Apply to this position